![]() ![]() "The generation of the callus is critically dependent on the recruitment of MSCs from the surrounding tissue and the bone marrow," explains lead author Assistant Professor Kenichi Kimura. The bone is then remodeled, as regular bone replaces the hard callus and the bone returns to its usual shape. These include clotted blood forming at the fracture, which becomes replaced by a callus of fibrous tissues and cartilage, followed by formation of a hard bony callus. The researchers therefore went on to study the functions of these CD73-positive MSCs in fracture healing.Īs a fracture heals, it progresses through various stages. The CD73-positive MSCs could be seen to proliferate more than the CD73- negative MSCs, and to have a higher potential to differentiate into different cell types, indicating that this group of MSCs may be particularly effective for bone repair. Studies of the bone marrow in this mouse revealed that a subpopulation of MSCs expressed CD73, as well as the sinusoidal endothelial cells (sECs) that are part of the vascular system of the bone marrow. The researchers had previously developed a mouse line that uses green fluorescent protein to highlight cells expressing a particular molecule known as CD73. ![]() ![]() MSCs are found in bone marrow, and are "multipotent," meaning that they can both renew themselves and develop into a variety of specialized cell types, such as bone, fat, and cartilage cells. ![]()
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